PDE-5 inhibitors - comparison of sexual enhancers


WHICH POTENCY PILL SUITS ME BEST?

Causes and treatment methods of ED

Erectile dysfunction rarely leads to another illness in most patients, and therefore, this state of health is not taken very seriously by health insurance companies. Impotence can have various causes, but if it is not caused by harmful involvement of the working conditions, the person concerned usually has to bear the full cost of the treatment himself.
The causes of impotence can be natural reasons such as old age or stress in the relationship, or other illnesses can cause them. Still, often it is unhealthy lifestyle habits that are considered the leading cause of erectile dysfunction. The most common methods of treating male sexual dysfunction include oral medicines (called PDE-5 inhibitors), topical medicines, mechanical aids such as vacuum pumps or penis rings, hormone therapy, and surgical interventions. The least invasive and, therefore, the most popular of all these treatment methods are oral pills Fildena 100 and vigora.

Effect of phosphodiesterase 5 inhibitors

At the moment, only oral erectile drug vigora 100 is used, which are based on one of the four phosphodiesterases 5 inhibitors - Viagra Sildenafil Citrate, Cialis Tadalafil, Levitra Vardenafil or Avanafil found. These PDE-5 inhibitors inhibit the cGMP-degrading enzyme phosphodiesterase, which usually contributes to the rapid termination of the erection, and thus leads to a more permanent enlargement of the blood vessels in the erectile tissue of the penis and a longer duration of the erection.
It goes without saying that these results can only be felt with simultaneous sexual stimulation. Strangely enough, the most common side effects do not include the feared adverse impact on blood pressure but complaints such as headache, facial flushing, indigestion, nasal congestion, back pain, and visual disturbances.
The four PDE-5 inhibitors sildenafil, Vardenafil, Tadalafil, and Avanafil mostly differ from each other only in the speed at which the effects occur, their duration, and compatibility with other ingested substances. Sildenafil Fildena is considered among the four to be the most effective erectile dysfunction in all age groups, Tadalafil as the longest-acting PDE-5 inhibitor, Vardenafil is the most sustainable alternative that is prescribed for older men who also have to use some other medications, with Avanafil being the fastest onset of action has.

Sildenafil Citrate

Sildenafil Citrate was the first PDE-5 inhibitor to be approved for the treatment of male erectile dysfunction in 1998 under the trade name Viagra. Sildenafil acts very quickly (the effect starts after about 30 minutes), is highly effective in both younger and older patients, and can also be prescribed off-label for the treatment of sexual dysfunction in female patients.
Sildenafil is the oldest, most commonly prescribed, and most widely prescribed PDE-5 inhibitor for impotence treatment, and therefore its side effects and interactions are well known and thoroughly documented. In addition to Viagra, this drug is the only active ingredient in various generic branded erectile medications such as Fildena 150mg, Kamagra, Cenforce 100, Suhagra, and Vigora used.
The disadvantages of Sildenafil include the weak effect while eating large and fatty meals and its relatively short duration of action. In addition to the treatment of erectile dysfunction, Sildenafil Citrate has also been approved under the trade name Revatio since 2006 for the treatment of idiopathic pulmonary arterial hypertension.
You must take Sildenafil about 30 minutes to 1 hour before you plan to engage in sexual activity. The effect of a dose lasts about 4 hours.

Tadalafil

Tadalafil is a drug that has been approved since 2003 under the trade name Cialis for the treatment of erectile dysfunction in male patients. It works similarly to Sildenafil. The effects start even faster than with Sildenafil and often last up to 36 hours. This makes Tadalafil the longest acting PDE-5 inhibitor. Another advantage is that it is well-tolerated with alcohol and full meals. Therefore, this sexual enhancer is suitable for men who want to eat complete and drink alcohol before sexual intercourse and want to pursue several sexual experiences in succession within 24-36 hours. Similar to Sildenafil Citrate, there are also soft chewable tablets and jellies, i.e., stomach-friendly and faster-acting forms of delivery of this active ingredient, which allow the patient to avoid any adverse effects on the digestive tract. Tadalafil is out Cialis also used in branded generics like Apcalis Oral Jelly, Tadacip and Tadalis Sx. At the end of 2012, Tadalafil was also approved for the treatment of the benign prostate syndrome.
It is recommended that you take Tadalafil about 15 minutes before you plan to have sex. The effect of a dose can last up to 36 hours.

Vardenafil

Vardenafil was approved as a second PDE-5 inhibitor under the trade name Levitra in March 2003 for the treatment of sexual dysfunction in male patients. Its mechanism of action is very similar to the above-mentioned PDE-5 inhibitors sildenafil and Tadalafil, and its duration of action is practically identical to that of Sildenafil. Its most significant advantage is its perfect compatibility with other medications. Therefore Vardenafil is mainly prescribed for the elderly who also have to take medications for the treatment of other health conditions regularly. The essential interactions include those with nitrite-containing drugs or NO donors and grapefruit juice. A disadvantage of Vardenafil can be called its slightly weaker effectiveness compared to Sildenafil Fildena 50 mg and Tadalafil, but, as with all other drugs, it depends on the individual patient. Vardenafil is currently only marketed as Levitra.
Vardenafil should be taken about 1 hour before you plan to engage in sexual activity. The effect starts in 15 to 60 minutes and usually lasts 5 to 6 hours.

Avanafil

Avanafil is the youngest drug from the PDE-5 inhibitor category used to address potency problems. This active ingredient was only approved in Germany in 2013 but is not yet available in some countries such as Switzerland. In Europe, this mono-preparation is known under the trade name Spedra whereby the trade name Stendra used in North America is known to many Germans. Avanafil (together with Tadalafil) has the fastest onset of action among all PDE-5 inhibitors, its efficiency is very high (about as high as that of the high-efficiency Sildenafil) and its half-life and therefore its duration of action of over 6 hours (sometimes even up to 12) Hours) lie between Sildenafil and Vardenafil on the one hand and the Tadalafil on the other side. Studies have shown that although Avanafil has the same high effectiveness as Sildenafil, the risk of a possible drop in blood pressure is lower. Thus the drug Avanafil should be more tolerable.
Avanafil should be used 15-30 minutes before planned sexual activity. The effect starts in about 15 minutes and will last for over 6 hours.

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